Decongestant nasal sprays and eye drops often contain oxymetazoline and are used for topical decongestion . Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists . The effects are not limited to the nose, and these medicines may cause hypertension (high blood pressure) through vasoconstriction ; it is for this reason that people with hypertension are advised to avoid them. Most decongestants, however, are not pronounced stimulants, due to lack of response from the other adrenoreceptors. Besides hypertension, common side-effects include sleeplessness, anxiety, dizziness, excitability, and nervousness.
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A total of 181 patients were randomly assigned to receive LX (n=94) and L (n=87). Baseline characteristics between the two groups were similar (mean age 40 years, 59% women). Overall, patient procedural discomfort with LX and L were +/- versus +/-, respectively (; 95% CI - to ). Transnasal insertion difficulty was significantly lower with LX than with L (+/- versus +/-, respectively [-; 95% CI - to -]). Compared with L, the use of LX was associated with significantly less time needed to apply anesthesia (+/- min versus +/- min, respectively [-; 95% CI - min to - min]) and less time for insertion (+/- min versus +/- min, respectively [- min; 95% CI - min to - min]). Epistaxis was rare but occurred less frequently with LX (%) than with L (%) (P=).