As an example, should you choose to run a cycle that includes both Dianabol and Anavar, you will need to be extremely careful when it comes to overlapping them. The two are both hepatotoxic, which means they will cause liver damage. You will need to consider this carefully when it comes to choosing cycle lengths. If you take Dianabol for four weeks at the beginning of your cycle, then make the switch to Anavar, you should limit your Anavar use to four weeks, as well. This reduces your entire cycle time to eight weeks, which helps to alleviate some of the risk of liver damage.
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]