Shake the drops gently to be sure the medicine is well mixed. Tilt your head back slightly and pull down on your lower eyelid. Position the dropper above your eye. Look up and away from the dropper. Squeeze out a drop and close your eye. Apply gentle pressure to the inside corner of your eye (near your nose) for about 1 minute to prevent the liquid from draining down your tear duct. If you are using more than one drop in the same eye, repeat the process with about 5 minutes between drops. If you are using drops in both eyes, repeat the process in the other eye.
The caudal approach to the epidural space involves the use of a Tuohy needle, an intravenous catheter, or a hypodermic needle to puncture the sacrococcygeal membrane . Injecting local anaesthetic at this level can result in analgesia and/or anaesthesia of the perineum and groin areas. The caudal epidural technique is often used in infants and children undergoing surgery involving the groin, pelvis or lower extremities. In this population, caudal epidural analgesia is usually combined with general anaesthesia since most children do not tolerate surgery when regional anaesthesia is employed as the sole modality.
An ointment of the present invention as prepared in Example 1 was tested in a bilateral paired psoriasis study using a conventional betamethasone 17,21-dipropionate ointment consisting of mg/g betamethasone 17,21-dipropionate, mg/g mineral oil and mg/g white petrolatum. Results of the bilateral paired comparison study [P values based on two-tailed sign test] indicate the ointment of Example 1 to be significantly (p ≦ ) more effective than the conventional ointment in the treatment of patients with chronic, stubborn psoriasis, based on the following results: