The good news is that prednisone moon face will go down, when the drug is discontinued. Because prednisone is a steroid, it affects the body's natural production of cortisol. If the prednisone is stopped too quickly, the body may not be able to adjust, and there could be serious health effects. Prednisone can not be stopped suddenly: the dosage must be tapered down. This means that when a physician determines that the dose can be lowered, it's lowered slowly over a period of days or months. How fast or slow the dosage is lowered depends on how long it has been taken, and how much was taken. Prednisone that is taken for a long time at high doses may need to be lowered very slowly, usually every week or few weeks. Usually, side effects such as moon face start to go away when the dosage is about 10 mg/day.