Over the study period, 92,938 CABG patients (%) received NSAIDs following surgery. The frequency of NSAID administration declined steadily over time, from a peak of % in 2004 to a low of % in 2010 (p < ). Ketorolac was the most frequent NSAID prescribed, commonly on the first postoperative day. Surgery performed after the boxed warning was independently associated with a 20% lower odds of NSAID administration [odds ratio (OR): ; p = ]. Other factors that predicted a lower odds of NSAID use following surgery included a history of renal disease (OR: ; p < ) and liver disease (OR: ; p < ), and the need for concurrent valve surgery (OR: ; p < ). A mammary graft at the time of surgery increased the odds of NSAID administration (OR: ; p < ).
Saponins from the Gypsophila paniculata (baby’s breath) plant have been shown to significantly augment the cytotoxicity of immunotoxins and other targeted toxins directed against human cancer cells. The research groups of Professor Hendrik Fuchs ( Charité University, Berlin, Germany) and Dr David Flavell (Southampton General Hospital, United Kingdom) are working together toward the development of Gypsophila saponins for use in combination with immunotoxins or other targeted toxins for patients with leukaemia , lymphoma and other cancers .