Certain drugs such as troleandomycin (TAO), erythromycin ( Ery-Tab , EryPed 200), and clarithromycin ( Biaxin ) and ketoconazole ( Nizoral ) can reduce the ability of the liver to metabolize (breakdown) corticosteroids and this may lead to an increase in the levels and side effects of corticosteroids in the body. On the other hand, phenobarbital, ephedrine , phenytoin ( Dilantin ), and rifampin ( Rifadin , Rimactane ) may reduce the blood levels of corticosteroids by increasing the breakdown of corticosteroids by the liver. This may necessitate an increase of corticosteroid dose when they are used in combination with these drugs.
Corticosteroids may play a useful role in cancer treatment. Since they are strongly anti-inflammatory they are sometimes prescribed to reduce swelling and pain. They may be used with other drugs to reduce nausea and vomiting created by chemotherapy treatment. They may also increase appetite. In a few types of cancer, specific corticosteroids are sometimes used with or without chemotherapy drugs to destroy cancer cells. It's important to note that while corticosteroids can be an important aspect of treatment in some types of cancer, they may not be helpful in all types.