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5 Do consider what’s causing persistent congestion. OTC nasal sprays are intended to relieve short-term congestion from such infections as the common cold, not to treat prolonged congestion. If your stuffiness lingers, ask your doctor what might be causing it, rather than overdoing it with sprays and risking the rebound effect. You could have an underlying problem such as allergies or a sinus infection. In those cases, the doctor might recommend a medication that’s more appropriate for chronic congestion, such as an antihistamine or a prescription nasal spray that contains a steroid.
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